Hannigan M, et al. Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc. Natl. Acad. Sci. USA. Mar 2002; 99(6): 3603-3608.
Santoro P, et al. Unconjugated bile acids modulate adult and neonatal neutrophil chemotaxis induced in vitro by N-formyl-met-leu-phe-peptide. Pediatr. Res. Mar 2002; 51(3): 392-6.
Full Name
N-Formyl-Met-Leu-Phe
Alias
MLF; M-L-F
Sequence (one-letter code)
N-Formyl-MLF
Sequence (three-letter code)
N-Formyl-{MET}{LEU}{PHE}
Description
N-formyl-methionyl-leucyl-phenylalanine (fMLP), the chemotactic bacterial peptide, was able to specifically attenuate Ca2+ mobilization in human phagocytes induced by SAA, but only at very high concentrations. The bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fMLF) is one of the first identified and highly potent leukocyte chemoattractants. fMLF interacts with at least two human cell receptors formyl peptide receptor (FPR) and its variant formyl peptide receptor-like 1 (FPRL1), both are members of the seven transmembrane domain, G protein-coupled receptor (GPCR) family.
Solubility
Insoluble in water. Dissolve dry peptide in small quantity of DMSO. When completely dissolved further dilute with desired buffer.
Formula
C21H31N3O5S1
M.W.
437.56
Cas
59880-97-6
Purity
> 95%
Storage
Store at -20°C. Keep tightly closed. Store in a cool dry place.
N-Terminal
Formylation
* For Non-Clinical Research Use Only *
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