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Orphanin FQ/Nociceptin, human, mouse, ox, rat

Cat. No. Size Price Figures
RP13084-0.5 mg
0.5 mg
$ 90.25
HPLC:  20060721145624  (PDF)
MS:  20060721145603  (PDF)
MSDS:  20080820223347  (PDF)

STRUCTURE:
Orphanin FQ/Nociceptin Example
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References:
  • Marti M, et al. Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. J. Neursci. Oct 2005; 25(42): 9591-9601.
  • Chung S, et al. Endogenous orphanin FQ / nociceptin is involved in the development of morphine tolerance. J. Pharmacol. Exp. Ther. Apr 2006.(Epub ahead of print).
Full Name
Orphanin FQ/Nociceptin, human, mouse, ox, rat
Sequence
(one-letter code)
FGGFTGARKSARKLANQ
Sequence
(three-letter code)
{PHE}{GLY}{GLY}{PHE}{THR}{GLY}{ALA}{ARG}{LYS}{SER}
{ALA}{ARG}{LYS}{LEU}{ALA}{ASN}{GLN}
DescriptionOrphanin FQ was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP-inding protein (G protein)-coupled receptor (LC132) that is similar in sequence to opioid receptors. Orphanin FQ has a primary structure reminiscent of that of opioid peptides. Nanomolar concentrations of orphanin FQ have inhibited forskolin-stimulated adenylyl cyclase activity in cells transfected with LC132. This inhibitory activity was not affected by the addition of opioid ligands, nor did the peptide activate opioid receptors. Orphanin FQ bound to its receptor in a saturable manner and with high affinity.
SolubilityThe peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
FormulaC79H129N27O22
M.W.1809.05
Cas170713-75-4
Purity> 95%
StorageStorage at -20°C. Keep tightly closed.
NotesIn conscious rats intravenous infusion of orphanin FQ produced a profound increase in urine flow rate and decrease in urinary sodium excretion.
* For Non-Clinical Research Use Only *
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