| |
Orphanin FQ/Nociceptin, human, mouse, ox, rat  |
|
|
| Cat. No. |
Size |
Price |
Figures |
|---|
RP13084-0.5 mg
| 0.5 mg | $ 90.00 | HPLC: 20060721145624 (PDF)
MS: 20060721145603 (PDF)
MSDS: 20080820223347 (PDF)
STRUCTURE:
Zoom
References:
- Marti M, et al. Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. J. Neursci. Oct 2005; 25(42): 9591-9601.
- Chung S, et al. Endogenous orphanin FQ / nociceptin is involved in the development of morphine tolerance. J. Pharmacol. Exp. Ther. Apr 2006.(Epub ahead of print).
|
|---|
| Full Name | | Orphanin FQ/Nociceptin, human, mouse, ox, rat |
|
| Alias |
Orphanin FQ,human, mouse, ox, rat |
Sequence
(one-letter code) |
FGGFTGARKSARKLANQ | Sequence
(three-letter code) | {PHE}{GLY}{GLY}{PHE}{THR}{GLY}{ALA}{ARG}{LYS}{SER}
{ALA}{ARG}{LYS}{LEU}{ALA}{ASN}{GLN} |
|---|
| Description | Orphanin FQ was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP-inding protein (G protein)-coupled receptor (LC132) that is similar in sequence to opioid receptors. Orphanin FQ has a primary structure reminiscent of that of opioid peptides. Nanomolar concentrations of orphanin FQ have inhibited forskolin-stimulated adenylyl cyclase activity in cells transfected with LC132. This inhibitory activity was not affected by the addition of opioid ligands, nor did the peptide activate opioid receptors. Orphanin FQ bound to its receptor in a saturable manner and with high affinity. |
|---|
| Solubility | The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. |
|---|
| Formula | C79H129N27O22 |
|---|
| M.W. | 1809.05 |
|---|
| Cas | 170713-75-4 |
|---|
| Purity | > 95% |
|---|
| Storage | Storage at -20°C. Keep tightly closed. | | Notes | In conscious rats intravenous infusion of orphanin FQ produced a profound increase in urine flow rate and decrease in urinary sodium excretion. |
|---|
| * For Non-Clinical Research Use Only *
 |
1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
|
2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $2.56 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
|
3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
|
4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
|
Our customer service is available 24 hours a day, Monday through Friday. You may contact us any time for assistance.
|
|
