| Cat. No. |
Size |
Price |
Figures |
|---|
RP13118-10 mg
| 10 mg | $ 25.00 | HPLC: 20050919140132 (PDF)
MASS SPECE: 20050919140154 (PDF)
MSDS: 20080820233010 (PDF)
STRUCTURE:
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References:
- Szabo G, et al. C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol. Acta. Physiol. Hung. 1987; 69(1): 115-122.
- Birkedal H, et al. N-Z-Pro-D-Leu using synchrotron radiation data from a very small crystal. Acta. Crystallogr C. Aug 2001; 57(Pt 8): 975-977.
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| Full Name | |
Sequence
(one-letter code) |
CBZ-PL |
Sequence
(three-letter code) | CBZ-{PRO}{d-LEU} |
|---|
| Description | The peptide CBZ-Pro-D-Leu, injected daily in mice receiving morphine chronically, is found to prevent development of physical dependence as measured by changes in body temperature and body weight due either to abrupt or to naloxone-induced withdrawal. But the peptide treatment did not alter the acute effects of a challenge dose of morphine on either analgesia or body temperature. |
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| Formula | C18H26N2O3 |
|---|
| M.W. | 362.42 |
|---|
| Purity | > 95% |
|---|
| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| N-Terminal | CBZ |
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| Notes | Effective in blocking development of tolerance to actions of morphine on pain threshold body temperature and weight. |
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