| Cat. No. |
Size |
Price |
Figures |
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RP13257-0.1 mg
| 0.1 mg | $ 104.50 | MSDS: 20080821023846 (PDF)
References:
- Wang HT, et al. Effect of EMP-1 gene on human esophageal cancer cell line. Ai Zheng. Mar 2002; 21(3): 229-232.
- Kasher R, et al. Design, synthesis, and evaluation of peptides with estrogen-like activity. Biopolymers. 2004; 76(5): 404-420.
- Lee HS, et al. EMP-1 is a junctional protein in a liver stem cell line and in the liver.Biochem. Biophys. Res. Commun. Sep 2005; 334.
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| Full Name | | Epithelial Membrane Protein (EMP)-1 |
|
| Alias |
EMP1; epithelial membrane protein-1; epithelial membrane protein |
Sequence
(one-letter code) |
GGTYSCHFGPLTWVCKPQGG |
Sequence
(three-letter code) | {GLY}{GLY}{THR}{TYR}{SER}{CYS}{HIS}{PHE}{GLY}{PRO}
{LEU}{THR}{TRP}{VAL}{CYS}{LYS}{PRO}{GLN}{GLY}{GLY} |
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| Chemical Bridge | Disulfide bond: Cys6-Cys15 |
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| Description | EMP-1 is identified as a surface biomarker whose expression correlates with acquisition of gefitinib resistance. EMP-1 expression is further correlated with lack of complete or partial response to gefitinib in lung cancer patient samples as well as clinical progression to secondary gefitinib resistance. EMP-1 expression and acquisition of gefitinib clinical resistance is independent of gefitinib-sensitizing EGFR somatic mutations. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
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| Formula | C94H133N25O26S2 |
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| M.W. | 2093.4 |
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| Purity | > 95% |
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| Storage | Before using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions. |
