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Dermorphin Analog |
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| Cat. No. |
Size |
Price |
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RP13522-0.5 mg
| 0.5 mg | $ 23.75 | HPLC: 20060721145624 (PDF)
MS: 20060721145604 (PDF)
MSDS: 20080909235451 (PDF)
References:
- Buczek O, et al. Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily. FEBS J. Aug 2005;272(16):4178-4188.
- Deguchi Y, et al. Blood-brain barrier permeability of novel [D-arg2]dermorphin (1-4) analogs: transport property is related to the slow onset of antinociceptive activity in the central nervous system. J Pharmacol Exp Ther. Jul 2004;310(1):177-184.
- Jinsmaa Y, et al. Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice. J Pharmacol Exp Ther. Apr 2004;309(1):432-438.
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| Full Name | | Sequence
(three-letter code) | TYR-d-ARG-PHE-SAR-TYR-PRO-SER-NH2 |
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| C-Terminal | NH2 |
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| Description | The dermorphin-derived peptide [Dmt1] dermorphin analog labels m-opioid receptors with high affinity and selectivity in receptor binding assays. In mice, radiant heat tail-flick assays, [Dmt1] dermorphin analog produces profound spinal and supraspinal analgesia, being approximately 5000 and 100 times more potent respectively than morphine in causing these analgesia on a molar basis. When administered systemically, [Dmt1] dermorphin analog has been shown to be over 200 times more potent than morphine. |
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| Solubility | Dermorphin analog is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. |
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| Formula | C44H59N11O10 |
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| M.W. | 901.43 |
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| Purity | > 95% |
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| Storage | Before use, store dermorphin analog in the DRY form at
0-5°C. For best and most repeatable results, rehydrate the peptide immediately before use. Do not re-freeze any unused portions. |
| * For Non-Clinical Research Use Only *
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