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[Des-Asp 1]-Angiotensin I, human  |
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| Cat. No. |
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Price |
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RP13717-5 mg
| 5 mg | $ 38.00 | HPLC: 20050919140132 (PDF)
MASS SPECE: 20050919140153 (PDF)
MSDS: 20080911230540 (PDF)
References:
- Nakano D, et al. Antihypertensive effect of Angiotensin I-converting enzyme inhibitory peptides from a sesame protein hydrolysate in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. May 2006; 70(5): 1118-26.
- Schorb W, et al. Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts. Circ. Res. Jun 1993; 72(6): 1245-1254.
- Husain A, et al. Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries. Proc. Natl. Acad. Sci. U.S.A. Apr 1987; 84(8): 2489-2493.
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| Full Name | | [Des-Asp1]-Angiotensin I, human |
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| Alias |
Ang I; AngiotensinI; Angiotensin 1; Angiotensin1 |
Sequence
(one-letter code) |
RVYIHPFHL | Sequence
(three-letter code) | {ARG}{VAL}{TYR}{ILE}{HIS}{PRO}{PHE}{HIS}{LEU} |
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| Description | The renin-angiotensin system plays an important role in regulating blood volume, arterial pressure, cardiac and vascular function, and may contribute to the pathogenesis of atherosclerosis. It stimulates an increase in nitric oxide synthase mRNA, protein expression, and nitric oxide production in pulmonary vessels. This system is found in various vertebrates, from elasmobranchs to mammals. Angiotensins consist of at least three polypeptide hormones: angiotensin I (Ang I), angiotensin II (Ang II), and angiotensin III (Ang III). Ang I is derived from a protein secreted by the liver by the action of renin, angiotensin, which then undergoes proteolytic cleavage to form the decapeptide Ang I. Ang I is converted to Ang II by the angiotensin converting enzyme (ACE) or kininase II, a dipeptidyl-carboxypeptidase. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
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| Formula | C58H84N16O11 |
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| M.W. | 1181.39 |
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| Purity | > 95% |
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| Storage | Storage at -20°C. Keep tightly closed. |
| * For Non-Clinical Research Use Only *
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