GenScript Catalog Peptide: [Sar<sup>1</sup>, Ile<sup>8</sup>]-Angiotensin II (RP13720)

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[Sar¹, Ile⁸]-Angiotensin II

Cat. No.

Size

Price

Figures

RP13720-5 mg

5 mg

$ 38.00

HPLC:  20060721145625  (PDF)
MS:  20060721145604  (PDF)
MSDS:  20080911232804  (PDF)

References:

TB Rogers, et al. High affinity angiotensin II receptors in myocardial sarcolemmal membranes. Characterization of receptors and covalent linkage of 125I-angiotensin II to a membrane component of 116,000 daltons. J Biol Chem. 1984 Jul 10;259(13):8106-14.
Ahsan Husain, et al. Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries. Proc. Natl. Acad. Sci. U.S.A. 1987 Apr;84(8):2489-93.
A Yoshida, et al. ACTH-induced inhibition of the action of angiotensin II in bovine zona glomerulosa cells. A modulatory effect of cyclic AMP on the angiotensin II receptor. J Biol Chem. 1991 Mar 5;266(7):4288-94.

Full Name

[Sar¹, Ile⁸]-Angiotensin II

Alias

AngiotensinII; Angiotensin 2; Angiotensin2

Sequence
(three-letter code)

{SAR}{ARG}{VAL}{TYR}{ILE}{HIS}{PRO}{ILE}

Description

The biological activities of angiotensin II antagonists upon basal and angiotensin II-stimulated aldosterone production were evaluated in an isolated canine glomerulosa cell preparation. Our investigations found that the most potent competitive antagonist of angiotensin II-stimulated aldosterone production was the [Sar1, Ile8] derivative of angiotensin II. However, this peptide was also a partial agonist at concentrations required to inhibit the steroidogenic effect of angiotensin II on dog adrenal cells, and never reduced aldosterone production to basal levels.

Solubility

GenScript angiotensin II is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.

Formula

C₄₆H₇₃N₁₃O₁₀

M.W.

968.15

Purity

> 95%

Storage

Storage at -20�C. Keep tightly closed.

* For Non-Clinical Research Use Only *

Precast Gels

Code	Name	Size	Price
RP11254	peptide : Angiotensin II (4-8), human	5 mg	$ 23.75
RP11253	peptide : Angiotensin II (3-8), human	5 mg	$ 23.75
RP11252	peptide : Angiotensin II (1-4), human	5 mg	$ 23.75

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