| Cat. No. |
Size |
Price |
Figures |
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RP17318-1 mg
| 1 mg | $ 66.00 | MSDS: 20080916015010 (PDF)
STRUCTURE:
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References:
- Kupiec JJ, Hazebrouck S et al. Conversion of thymidylate synthase into an HIV protease substrate. J Biol Chem. Aug 1996;271(31):18465-70.
- Katoh E, Louis JM et al. A solution NMR study of the binding kinetics and the internal dynamics of an HIV-1 protease-substrate complex. Protein Sci. Jul 2003;12(7):1376-85.
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| Full Name | |
Sequence
(one-letter code) |
AC-ARVLAEA-NH2 |
Sequence
(three-letter code) | AC-{ALA}{ARG}{VAL}{LEU}{ALA}{GLU}{ALA}-NH2 |
|---|
| C-Terminal | NH2 |
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| Description | The insertion of Human immunodeficiency virus type 1 (HIV-1) protease substrate sequences into the permissive sites converted TS to an HIV-1 protease substrate, and the in vivo cleavage of these insertions by the cloned HIV-1 protease conferred a thymidylate synthase-deficient phenotype in some of our E. coli mutant strains. The permissive sites are located in regions of the TS protein not essential for enzyme activity and accessible to cleavage by HIV protease. |
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| Formula | C33H59N11O10 |
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| M.W. | 769.89 |
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| Purity | > 95% |
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| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| N-Terminal | AC |
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