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| Opioid Receptor Antagonist |
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| Cat. No. |
Size |
Price |
Figures |
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RP17327-1 mg
| 1 mg | $ 49.50 | MSDS: 20080917221053 (PDF)
STRUCTURE:
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References:
- Watanable H, et al. A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse. J. Pharmacol. Exp. Ther. Mar 2005; 312(3): 1075-1081.
- Mague SD, et al. Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J. Pharmacol. Exp. Ther. Apr 2003; 305(1): 323-330.
- Hosohata k, et al. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. J. Pharmacol. Exp. Ther. Feb 2003; 304(2): 683-688.
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| Full Name | | Opioid Receptor Antagonist |
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Sequence
(one-letter code) |
RFMWMK ;
RFMWMR ;
RFMWMT. | Sequence
(three-letter code) | {ARG}{PHE}{MET}{TRP}{MET}{LYS};
{ARG}{PHE}{MET}{TRP}{MET}
{ARG};
{ARG}{PHE}{MET}{TRP}{MET}{Thr}. |
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| C-Terminal | NH2 |
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| Description | Opioid receptor antagonist showed high affinity for μ and κ3 opioid receptors, somewhat lower affinity for δ receptors, weak affinity for κ1 receptors, and no affinity for κ2 receptors. They were found to be potent μ receptor antagonists in the guinea pig ileum assay and relatively weak antagonists in the mouse vas deferens assay. These Opioid receptor antagonist represent a class of opioid receptor ligands that we have termed acetalins (acetyl plus enkephalin).
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| Purity | > 95% |
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| Storage | Store at -20°C | | N-Terminal | AC |
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