| Catalog No. |
Size |
Price |
Figures |
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Z00008-1 mg
| 1 mg | $ 420.00 |
References:
- Chan CK,et al. Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions. J. Virol. Sep 2002; 76(17): 8667-8674.
- Loveland AN,et al. Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. J. Virol. Oct 2005; 79(20): 12961-12968.
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| Full Name | | CytomegaloVirus (CMV) Pp38 (UL80a) |
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| Abbreviated Name-1 | CMV Pp38; CMVPp38; CMV Pp38; |
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| Description | CytomegaloVirus (CMV) Pp38 (UL80a) is considered one of the most common viral infections in man. The virus rarely causes disease, but may persist as a latent or chronic infection of the salivary glands, renal tubules, cervix and leukocytes. The incidence and spectrum of the disease in newborns and immunocompromised hosts establish the virus as an important human pathogen. CMV infections are frequent and occasionally severe in children or adults with congenital or acquired defects of cellular immunity, such as patients with AIDS, cancer patients, and recipients of organ transplants. The transmission of CMV via transfused blood may account for most CMV infections in organ transplant recipients, neonates, and heart surgery patients. Medical conditions caused by CMV include: interstitial pneumonia, mononucleosis (heterophile negative), congenital defects, abortion, mental retardation, blindness and deafness. CytomegaloVirus Pp38 (UL80a) was E. coli derived recombinant. The protein contains the CMV Pp38(UL80a) immunodominant regions. |
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| Source | E. coli |
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| Purity | Protein is >95% pure as determined by 10% PAGE (coomassie staining). |
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| Specific Activity | Immunoreactive with sera of CMV-infected individuals. |
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| Storage | Protein is shipped at ambient temperature. Upon arrival, store at -20°C. |
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| Concentration | 1 mg/ml in 25 mM Tris-Hcl pH7.2, 1 mM EDTA, 50% glycerol. |
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| Stability | Five years frozen. One month in solution at room temperature. |
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| Specificity | Immunoreactive with sera of CMV-infected individuals. |
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| Applications | Antigen in ELISA and Western blots, excellent antigen for detection of CMV with minimal specificity problems. |
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