| Catalog No. |
Size |
Price |
Figures |
|---|
Z00375-10 ug
| 10 ug | $ 91.00 |
References:
- Dimitriadis E, et al. Interleukin-11, IL-11 receptoralpha and leukemia inhibitory factor are dysregulated in endometrium of infertile women with endometriosis during the implantation window. J. Reprod. Immunol. Feb 2006; 69(1): 53-64.
- Dimitriadis E, et al. Interleukin 11 Signaling Components Signal Transducer and Activator of Transcription 3 (STAT3) and Suppressor of Cytokine Signaling 3 (SOCS3) Regulate Human Endometrial Stromal Cell Differentiation. Endocrinology. Aug 2006; 147(8): 3809-3817.
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Z00375-50 ug
| 50 ug | $ 320.00 |
|---|
Z00375-1 mg
| 1 mg | $ 1600.00 |
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| Full Name | | Interleukin (IL)-11, human |
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| Abbreviated Name-1 | rHuIL-11 |
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| Abbreviated Name-2 | IL11; Interleukin-11; Interleukin11 |
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| Description | Interleukin (IL)-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. IL-11 is a multifunctional cytokine that has pleiotropic effects on a variety of tissue including the bone marrow and intestinal mucosa. IL-11 also stimulates proliferation of primitive stem cells and multipotential and committed progenitor cells from various sources including cord blood, bone marrow, and peripheral blood in different culture systems and increases the commitment of primitive stem cells into the progenitor cell compartment. IL-11 sustains hematopoiesis resulting in an increased number of megakaryocytes and erythropoiesis, lymphopoiesis, and myelopoiesis. IL-11 acts synergistically with other early and late acting growth factors that stimulate various stages and lineages of hematopoiesis. |
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| Source | P. Pichia |
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| M.W. | 19.2 KD+/-10% determined by reduced SDS-PAGE |
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| UV Scan | The maximal absorption wave is 278+/-3 nm. |
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| Purity | Greater than 95% as determined by
(a) Analysis by SEC-HPLC.
(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Residual DNA: less than 2 ng/mg analysis by solid phase blot.
Residual host cell protein: less than 0.1% analysis by ELISA. |
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| Endotoxin Level | Less than 2 ng/mg (2 IEU/μg) determined by LAL test |
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| Specific Activity | The specific activity as determined was found to be greater than 8.0×106 IU/mg. |
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| Storage | Lyophilized rHuIL-11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-11 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
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| Formulation | The protein was lyophilized from a concentrated (1 mg/ml) solution with no additives. |
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| Reconstitution | It is recommended to reconstitute the lyophilized rHuIL-11 in sterile 18 MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions. |
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| Sequence analysis | The sequence of the first fifteen N-terminal amino acids was determined and was found to be Gly-Pro-Pro-Pro-Gly-Pro-Pro-Arg-Val-Ser-Pro-Asp-Pro-Arg-Ala.
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