| Catalog No. |
Size |
Price |
Figures |
|---|
Z02061-10 ug
| 10 ug | $ 75.00 | |
|---|
Z02061-50 ug
| 50 ug | $ 250.00 |
|---|
Z02061-1 mg
| 1 mg | $ 2300.00 |
|---|
| Full Name | | Interleukin (IL)-17, human |
|
| Abbreviated Name-1 | Interleukin-17; Interleukin17; IL17 |
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| Description | The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. GenScript Interleukin (IL)-17, human is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains. |
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| Source | E. coli |
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| M.W. | 15,000 Da |
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| Purity | Greater than 95% by SDS-PAGE analyses |
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| Endotoxin Level | Less than 1 EU/µg as determined by LAL method |
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| Specific Activity | The ED50 as determined by the dose-dependent induction of IL-6 in Hs68 cell line was found to be approximately 2 ng/ml. |
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| Storage | Lyophilized IL-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA oor BSA). |
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| Formulation | Sterile filtered lyophilized (freeze-dried) powder, with 20 mM Citrate, 0.1 M NaCl, pH 4.5 |
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| Reconstitution | It is recommended to reconstitute the lyophilized IL-17 in sterile 18 MΩ-cm H2O no less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
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| Stability | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
Reconstituted human IL-17 should be stored in working aliquots at -20°C.
Avoid repeated freeze-thaw cycles.
|
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| Applications | FOR RESEARCH USE ONLY. NOT FOR HUMAN USE. |
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| Sequence analysis | The sequence of the first 5 N-terminal amino acids was determined and was found to be Met-Gly-Ile-Thr-Ile. |
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