gene dosage PCR (gd-PCR)
A method for quantification of the relative amount of a gene in a biological sample. One primer is constructed to hybridize with a gene known to be in the chromosome in question (e.g. chromosome 21 in the case of Down's syndrome) and another to hybridize to an unrelated gene in a different chromosome. Quantification of the amplified PCR products is sufficiently precise to distinguish a 50% increase in the chromosome 21 gene. Taylor, G.R. and Logan, W.P. (1995) Curr. Opin. Biotechnol. 6, 24-29
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