Monod-Wyman-Changeux (MWC) model
A concerted model for the basis of co-operativity in multimeric binding proteins, originally presented as a description of oxygen binding to each of the haem groups of the haemoglobin tetramer. In the absence of a ligand (oxygen in the case of haemoglobin) the subunits exist in a low-affinity 'taut' conformation (tense form). The ligand may bind to as many as two monomers in this conformation, at which point all four monomers convert from the low-affinity form to the high-affinity 'relaxed' conformation (R-form). (see also Koshland model (KNF model))
|
|
| GenScript Hot Products & Services: |
|
| |
Return to Search Page
If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send details to the Editorial Office at GenScript.
