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paradox of Levinthal paradox of Levinthal The incompatibility between the enormous number of conformations an unfolded protein may assume and the rapidity with which it achieves its native conformation. The proposed resolution was folding pathways, the attainment of the native conformation by passage through a series of fairly well-defined on-pathway intermediates; if no kinetic barrier to refolding was detected, this reduced to a two-state model; if a barrier was detected, this was explained in terms of off-pathway kinetic dead-ends, or high energy transition states. (see framework model, funnel concept)(see framework model; funnel concept)

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