quadruplex DNA
A form of DNA in which four oligo(G) sequences, either of the same or of different strands, LINE up either in a parallel, an anti-parallel or in a fold-back (mixed parallel and antiparallel) pattern. The interior of quadruple the helix has four guanine bases in Hoogstein base pairings; each plane of four guanines is separated from the adjacent plane by a Na+ or K+ ion. Although these structures have not been identified cells, they are strongly suspected to cap the ends of chromosomal DNA. see telomerePalecek, E. (1991) Crit. Rev. Biochem. Mol. Biol. 26, 151-226; Yagil, G. (1991) Crit. Rev. Biochem. Mol. Biol. 26, 475-559; Borman, S. (1998) Chem. Eng. News 76 (40) 42-46
|
|
|
Return to Search Page
If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send details to the Editorial Office at GenScript.
