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base flipping The distortion of a double-stranded DNA structure that disrupts a base pair and redirects one nucleoside of the pair outwards, where it can interact with a DNA-modifying enzyme such as a methyltransferase. Kunkel, T.A. and Wilson, S.H. (1996) Nature (London) 384, 25-26; Roberts, R.J. and Cheng, X. (1998) Annu. Rev. Biochem. 67, 181-198

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