yeast artificial chromosome (YAC) A cloning vector that can accept a relatively large fragment of foreign DNA, up to 1Mb, in yeast cells. (see also BACterial artificial chromosome (BAC); cosmid)Watson, J.D., Gilman, M., Witkowski, J. and Zoller, M. (1992) Recombinant DNA, 2nd edn., pp. 590-592, Scientific American Books, New York
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