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Cornish-Bowden plot A graphical method for determination of the type of enzyme inhibition and the dissociation constant for an enzyme-inhibitor complex (Ki) or for an enzyme-inhibitor-substrate complex (Ki'). The effect on the enzymic rate (v) is determined at two or more substrate concentrations (S) and over a range of inhibitor concentrations (I). In a plot of S/v versus I, the data for each substrate concentration fall on straight lines that intersect at I=-Ki and S/v=Km/Vmax (uncompetitive inhibition), or intersect on the abscissa (S/v=0) at I=-Ki (non-competitive inhibition). For competitive inhibition, the lines are parallel. (see also Dixon plot; Easson and Stedman plot; Hunter and Downs plot)

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