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centromere The constriction of a chromosome seen in metaphase at which pairs of sister chromatids are held together and which is the site of attachment of a chromatid to the mitotic spindle.Choo, K.H.A. (1998) Nat. Genet. 18, 3-4; Clarke, L. (1998) Curr. Opin. Genet. Develop. 8, 212-218

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