CMV Pp38 (UL80a), CytomegaloVirus Antigen, Recombinant

Full Name

Abbreviated Name-1

CMV Pp38; CMVPp38; CMV Pp38;;

Documents
Figures
Reference
Chan CK,et al. Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions. J. Virol. Sep 2002; 76(17): 8667-8674. Loveland AN,et al. Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. J. Virol. Oct 2005; 79(20): 12961-12968.

Description

CytomegaloVirus (CMV) Pp38 (UL80a) is considered one of the most common viral infections in man. The virus rarely causes disease, but may persist as a latent or chronic infection of the salivary glands, renal tubules, cervix and leukocytes. The incidence and spectrum of the disease in newborns and immunocompromised hosts establish the virus as an important human pathogen. CMV infections are frequent and occasionally severe in children or adults with congenital or acquired defects of cellular immunity, such as patients with AIDS, cancer patients, and recipients of organ transplants. The transmission of CMV via transfused blood may account for most CMV infections in organ transplant recipients, neonates, and heart surgery patients. Medical conditions caused by CMV include: interstitial pneumonia, mononucleosis (heterophile negative), congenital defects, abortion, mental retardation, blindness and deafness. CytomegaloVirus Pp38 (UL80a) was E. coli derived recombinant. The protein contains the CMV Pp38(UL80a) immunodominant regions.

Source

E. coli

Purity

Protein is >95% pure as determined by 10% PAGE (coomassie staining).

Specific Activity

Immunoreactive with sera of CMV-infected individuals.

Storage

Protein is shipped at ambient temperature. Upon arrival, store at -20°C.

Concentration

1 mg/ml in 25 mM Tris-Hcl pH7.2, 1 mM EDTA, 50% glycerol.

Stability

Five years frozen. One month in solution at room temperature.

Specificity

Immunoreactive with sera of CMV-infected individuals.

Applications

Antigen in ELISA and Western blots, excellent antigen for detection of CMV with minimal specificity problems.

Note

;

Related Products

Cat. No.	Name	Size	Price
RP11781	CEF20	1 mg	$71
RP11782	CEF21	1 mg	$71
Z00010	CMV Pp65 (UL83), CytomegaloVirus Antigen, Recombinant	1 mg	$1000


1	Custom Recombinant Protein Services: Guaranteed E. coli Expression Package-3 mg purified soluble protein from $2,200 .
2	Bacterial Expression System: GenScript has developed BacPower^TM technologies to tackle hard-to-express and hard-to-dissolve proteins.
3	Yeast Expression System: GenScript's proprietary YeastHIGH^TM technology combines the advantages of the bacterial and eukaryotic expression systems.
4	Baculovirus/Insect Cell Expression System: GenScript developed BacuVance^TM platform for the secretion of recombinant proteins from baculovirus-infected insect cells.
5	Mammalian Cell Expression System: The proprietary 293 and CHO suspension system platform promotes fast production and delivery of recombinant proteins and monoclonal antibodies up to grams level.