Pegylated Granulocyte Colony Stimulating Factor (PEG-G-CSF), human

*This product has been discontinued!*

Human pegylated granulocyte colony stimulating factor (PEG-GCSF) produced in E. coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 18,800 Da. pegylated granulocyte colony stimulating factor (PEG-GCSF) is manufactured by attaching a 20,000 Da methoxypolyethylene glycol propionaldehyde (mPEG-ALD) to the N-terminal amino acid of G-CSF having a total molecular mass of 38,800 Da.

Cat. No.	Z00393
Size	Buy in bulk

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Product Introduction Background

Product Introduction

Purity	Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by reducing and non-reducing SDS-PAGE silver-stained gel.
Endotoxin Level	Less than 0.1 ng/µg (1 IEU/µg) of rHuPEG-G-CSF.
Formulation	The protein was lyophilized after extensive dialysis against 10mM HAc-NaAc, pH4.0, 150mM NaCl, 0.004% Tween 80, 5% Mannitol buffer.

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Background

Target Background

Human pegylated granulocyte colony stimulating factor (PEG-GCSF) produced in E. coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 18,800 Da. pegylated granulocyte colony stimulating factor (PEG-GCSF) is manufactured by attaching a 20,000 Da methoxypolyethylene glycol propionaldehyde (mPEG-ALD) to the N-terminal amino acid of G-CSF having a total molecular mass of 38,800 Da.

Synonyms

rHuPEG-G-CSF; PEG-G-CSF

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Citations

1. Hotson AN, et al. Coordinate actions of innate immune responses oppose those of the adaptive immune system during Salmonella infection of mice. Sci Signal. (2016)
2. Gopinath S, et al. The Systemic Immune State of Super-shedder Mice Is Characterized by a Unique Neutrophil-dependent Blunting of TH1 Responses. PLoS Pathog. (2013-06)