Catalog Products » Cytokines » Interleukin-17 (IL-17), human
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Interleukin-17 (IL-17), human

*This product has been discontinued!*
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. GenScript Interleukin (IL)-17, human is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
Z02061
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Product Introduction
Purity Greater than 95% by SDS-PAGE analyses
Endotoxin Level Less than 1 EU/µg as determined by LAL method
Formulation Sterile filtered lyophilized (freeze-dried) powder, with 20 mM Citrate, 0.1 M NaCl, pH 4.5
Reconstitution It is recommended to reconstitute the lyophilized IL-17 in sterile 18 MΩ-cm H2O no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
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Applications
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE.
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Background
Target Background The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. GenScript Interleukin (IL)-17, human is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
Synonyms Interleukin-17; Interleukin17; IL17;
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