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ErbB3 Fragment (ErbB3-f), Human



Cat. No.
Name
Size   
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Selected
Z02748-20
20 μg
$135

Protein ErbB3 Fragment (ErbB3-f), Human
Synonyms
ErbB3 Fragment (ErbB3-f), Human;
Documents
ErbB3-f, HumanDocument-MSDS: Z02748-MSDS.pdf (pdf)
Species
Human
Purity
>95% by SDS-PAGE and HPLC analyses.
Endotoxin Level
Less than 0.2EU/ug of rHuErbB3-f as determined by LAL method.
Biological Activity
Fully biologically active. Measured by its ability to postpone tumor emerge time of spontaneous breast cancer in FVB/N transgenic mice and inhibit the development of tumor, effectively inhibit the growth of in situ transplanted breast cancer in FVB/N transgenic mice.
Source
E. coli
Amino Acid Sequence
SEVGNSQAVC PGTLNGLSVT GDAENQYQTL YKLYERCEVV
MGNLEIVLTG HNADLSFLQW IREVTGYVLV AMNEFSTLPL
PNLRVVRGTQ VYDGKFAIFV MLNYNTNSSH ALRQLRLTQL
TEILSGGVYI EKNDKLCHMD TIDWRDIVRD RDAEIVVKDN
GRSCPPCHEV C
Molecular Weight
Approximately 34 kDa, a single non-glycosylated fusion polypeptide chain, containing 171 amino acids (Ser20-Cys190) with N-terminus Thioredoxin Tag and His tag.
Description
ErbB3, also called Her3 (human epidermal growth factor receptor 3), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. Among ErbB family members, ErbB3 is unique in that it contains a defective kinase domain. ErbB3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric ErbB3 serves as a low affinity receptor for the heregulins (HRG).rhErbB3-f is a recombinant genetic engineering product which expressed in E. Coli. RhErbB3-f can induce specific antibody production in vivo, hence to inhibit tumor cell growth. The product can be used to treat early, medium and advanced or post-operative breast cancer patients with over-expression of ErbB2. According to its mechanism of action, rhErbB3-f is classified into therapeutic cancer vaccine.
Formulation
A white, semitransparent suspension in 1mg aluminum hydroxide and small amount of arginine, sodium chloride, sodium phosphate, and potassium phosphate.
Reconstitution
It is recommended that sterile phosphate-buffered saline containing 1mg aluminum hydroxide be added to the vial to prepare a stock solution.
Storage
This liquid suspension is stable for several months at 0-4°C, but should be kept at -20°C for long term storage. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Physical Appearance
A white semitransparent suspension at a concentration of 1 mg/ml.
Usage
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Document-COA
  • Z02748_R50051204.pdf
  • Z02748_R52021204.pdf
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