Interferon-gamma ( IFN-γ), Mouse

*This product has been discontinued!*

Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature Interferon-gamma exists as noncovalently-linked homodimers. Human Interferon-gamma is highly species specific and is biologically active only in human and primate cells. Interferon-gamma was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. Interferon-gamma induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Interferon-gamma also augments TH1 cell expansion and may be required for TH1 cell differentiation.

Cat. No.	Z02781
Size	Buy in bulk

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Product Introduction Background

Product Introduction

Purity	>95% by SDS-PAGE and HPLC analyses.
Endotoxin Level	Less than 0.2EU/mg of recombinant Mouse Interferon-gamma as determined by LAL method.
Formulation	Lyophilized from a 0.2µm filtered solution in PBS, pH 7.4, containing 5% trehalose.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

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Background

Target Background

Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature Interferon-gamma exists as noncovalently-linked homodimers. Human Interferon-gamma is highly species specific and is biologically active only in human and primate cells. Interferon-gamma was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. Interferon-gamma induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Interferon-gamma also augments TH1 cell expansion and may be required for TH1 cell differentiation.

Synonyms

Interferon-gamma ( IFN-γ), Mouse;

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