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MCP-4/CCL13, Human



Cat. No.
Name
Size   
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Selected
Z02836-1
1 mg
$2,100
Z02836-20
20 μg
$159

Protein MCP-4/CCL13, Human
Abbreviated Name-1
MCP-4/CCL13, Human;
Documents
MCP-4/CCL13, HumanDocument-MSDS: 15372_20120105035047.PDF (PDF)
Species
Human
Purity
> 96 % by SDS-PAGE and HPLC analyses.
Endotoxin Level
Less than 1 EU/μg of rHuMCP-4/CCL13 as determined by LAL method.
Biological Activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 10-100 ng/ml.
Source
E. coli
Amino Acid Sequence
QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV
IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT
Molecular Weight
Approximately 8.6 kDa, a single non-glycosylated polypeptide chain containing 75 amino acids.
Description
CCL13 is a chemoattractant for monocytes and eosinophils, and activates basophils. In addition, it has been reported to be chemotactic for CD4+ and CD8+ T cells, with an activity almost equivalent to that of MCP-3. The bioactivities of CCL13 is most likely mediated by the CC chemokine receptors CCR-2 and CCR-3, both of which have been shown to bind CCL13.
Synonyms
MCP-4/CCL13, Human;
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 130 mM NaCl.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
Storage
This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Usage
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Document-COA
  • Z02836_R51181204.pdf
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