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Bone Morphogenetic Protein-2 (BMP-2), Human

Cat. No.
50 µg
1 mg
10 μg
100 µg

Full Name Bone Morphogenetic Protein-2 (BMP-2), Human
Abbreviated Name-1
BMP-2, BMP2A, Bone morphogenetic protein 2, BMP-2A, BMP2
Bone Morphogenetic Protein-2 (BMP-2), HumanDocument-COA: COA of Human BMP-2.pdf (pdf)
Bone Morphogenetic Protein-2 (BMP-2), HumanDocument-MSDS: MSDS of Human BMP-2.pdf (pdf)
Bone Morphogenetic Protein-2 (BMP-2), HumanDocument-COA: COA of Human BMP-2.pdf (PDF)
Bone Morphogenetic Protein-2 (BMP-2), HumanDocument-COA: COA of Human BMP-2_P20011210_.pdf (PDF)
Bone Morphogenetic Protein-2 (BMP-2), HumanDocument-COA: P50011308_Z02913_COA.pdf (PDF)
Sampath, T.K. et al., Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. J Biol Chem. 1990 Aug 5;265(22):13198-205.

Heng S. et al., Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. Endocrinology. 2010 Aug;151(8):3909-17. Epub 2010 Jun 16.

Celeste, A. J. et al., Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9843-7.

Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). The active form consists of a dimer of two identical proteins which are linked by a disulfide bond at Cys360. It plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction.

Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 115 amino acids. A fully biologically active molecule, rhBMP-2 has a molecular mass of 26 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
E. coli
26 kDa, observed by non-reducing SDS-PAGE
> 95% as analyzed by non-reducing SDS-PAGE.
Endotoxin Level
< 1 EU/μg, determined by LAL method.
Specific Activity
ED50 < 1 μg/ml, measured by alkaline phosphatase induction assay using C2C12 cells.
Lyophilized recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-2 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Lyophilized after extensive dialysis against 50 mM acetic acid.
Reconstituted in 20 mM AcOH or 5 mM HCl. The solubility should be at 100 μg/ml.

Gln283-Arg396 (accession number:P12643). Expressed
with an N-terminal Met.
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