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Bone Morphogenetic Protein-2 (BMP-2), Human



Cat. No.
Name
Size   
Price
Selected
Z02913-10
10 μg
$85
Z02913-100
100 µg
$479
Z02913-50
50 µg
$268
Z02913-1
1 mg
$1,600

Protein Bone Morphogenetic Protein-2 (BMP-2), Human
Synonyms
BMP-2, BMP2A, Bone morphogenetic protein 2, BMP-2A, BMP2
Documents
BMP-2, HumanDocument-MSDS: MSDS of Human BMP-2.pdf (pdf)
Figures
BMP-2, Human zoomBMP-2, Human
BMP-2, Human zoomBMP-2, Human
BMP-2, Human zoomBMP-2, Human
Species
Human
Purity
> 95% as analyzed by non-reducing SDS-PAGE and HPLC analyses
Endotoxin Level
< 1 EU/μg, determined by LAL method.
Biological Activity
Assay #1: Measured by its ability to induce alkaline phosphatase production by ATDC-5 Cells, The ED50 for this effect is typically 0.07-0.2 µg/mL.
Assay #2: Measured by its ability to induce alkaline phosphatase production by C2C12 cells, The ED50 for this effect is typically 0.2-1 µg/mL.
Source
E. coli
Amino Acid Sequence
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH
AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC
VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Molecular Weight
26 kDa, observed by non-reducing SDS-PAGE
Formulation
Lyophilized after extensive dialysis against 50 mM acetic acid.
Reconstitution
Reconstituted in 20 mM AcOH or 5 mM HCl. The solubility should be at 100 μg/ml.
Storage
Lyophilized recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-2 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note
Document-COA
  • P20011203_Z02913_COA.pdf
  • P20011208_Z02913_COA.pdf
  • P20011210_Z02913_COA.pdf
  • P50011308_Z02913_COA.pdf
  • P50131409_Z02913_COA.pdf
  • Citation
    Sven Saldanha., et al Caveolae regulate smad signaling as verified by novel imaging and system biology approaches. J Cell Physiol. 2013 May;228(5):1060-9.

    Moseychuk O., et al Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes.J Cell Commun Signal. 2013 Dec;7(4):265-78.

    Jeremy Bonor., et al Initiation of BMP2 signaling in domains on the plasma membrane.J Cell Physiol. 2012 Jul;227(7):2880-8.

    John C., et al Design, fabrication and in vitro evaluation of a novel polymer‐hydrogel hybrid scaffold for bone tissue engineering. J Tissue Eng Regen Med. 2012 Jun 11.

    Chanchareonsook N., et al Segmental mandibular bone reconstruction with a carbonate-substituted hydroxyapatite-coated modular endoprosthetic poly(ɛ-caprolactone) scaffold in Macaca fascicularis. J Biomed Mater Res B Appl Biomater. 2013 Nov 21.



    A Clark., et al. Mechanical Properties and Dual Drug Delivery Application of PLGA Scaffolds Fabricated with a Poly (β-amino ester) Porogen. Acta Biomater. 2014Jan.

    E Alegre-Aguarón., et al. Growth Factor Priming Differentially Modulates Components of the Extracellular Matrix Proteome in Chondrocytes and Synovium-Derived Stem Cells. PLoS One. 2014Feb.;9(2):e88053

    Cushnie EK., et al. Simple Signaling Molecules for Inductive Bone Regenerative Engineering. PLoS One. 2014July;9(7):e101627

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