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Bone Morphogenetic Protein-2 (BMP-2), Human

Cat. No.
10 μg
100 µg
50 µg
1 mg

Protein Bone Morphogenetic Protein-2 (BMP-2), Human
BMP-2, BMP2A, Bone morphogenetic protein 2, BMP-2A, BMP2
BMP-2, HumanDocument-MSDS: MSDS of Human BMP-2.pdf (pdf)
BMP-2, Human zoomBMP-2, Human
> 95% as analyzed by non-reducing SDS-PAGE.
Endotoxin Level
< 1 EU/μg, determined by LAL method.
Biological Activity
ED50 < 1 μg/ml, measured by alkaline phosphatase induction assay using C2C12 cells.
E. coli
Amino Acid Sequence
Gln283-Arg396 (accession number: P12643 ). Expressed with an N-terminal Met.
Molecular Weight
26 kDa, observed by non-reducing SDS-PAGE
Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). The active form consists of a dimer of two identical proteins which are linked by a disulfide bond at Cys360. It plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction.

Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 115 amino acids. A fully biologically active molecule, rhBMP-2 has a molecular mass of 26 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
Lyophilized after extensive dialysis against 50 mM acetic acid.
Reconstituted in 20 mM AcOH or 5 mM HCl. The solubility should be at 100 μg/ml.
Lyophilized recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-2 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
  • COA of Human BMP-2.pdf
  • COA of Human BMP-2.pdf
  • COA of Human BMP-2_P20011210_.pdf
  • P20011208_Z02913_COA.pdf
  • P20011210_Z02913_COA.pdf
  • P50011308_Z02913_COA.pdf
  • Citation
    Sven Saldanha., et al Caveolae regulate smad signaling as verified by novel imaging and system biology approaches. J Cell Physiol. 2013 May;228(5):1060-9.

    Moseychuk O., et al Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes.J Cell Commun Signal. 2013 Dec;7(4):265-78.

    Jeremy Bonor., et al Initiation of BMP2 signaling in domains on the plasma membrane.J Cell Physiol. 2012 Jul;227(7):2880-8.

    John C., et al Design, fabrication and in vitro evaluation of a novel polymer‐hydrogel hybrid scaffold for bone tissue engineering. J Tissue Eng Regen Med. 2012 Jun 11.

    Chanchareonsook N., et al Segmental mandibular bone reconstruction with a carbonate-substituted hydroxyapatite-coated modular endoprosthetic poly(ɛ-caprolactone) scaffold in Macaca fascicularis. J Biomed Mater Res B Appl Biomater. 2013 Nov 21.

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