BX/SVTLE, Reptile

*This product has been discontinued!*

Batroxobin is a serine protease derived from the venom of Bothrops atrox. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A (alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin clotting time' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets.

Cat. No.	Z02963
Size	Buy in bulk

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Product Introduction Background

Product Introduction

Species	Reptile
Purity	>97% by SDS-PAGE and HPLC analyses.
Endotoxin Level	Less than 0.5EU/mg of rRpBX/SVTLE as determined by LAL method.
Formulation	Lyophilized from a 0.2μm filtered concentrated sodium acetate buffer solution.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilutions should be made in appropriate buffered solutions.

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Background

Target Background

Synonyms

Thrombin-like enzyme batroxobin, EC 3.4.21.74, BX, Bothrops atrox serine proteinase, Venombin-A, Defibrase, Reptilase, Batroxobin.

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