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Fibroblast Growth Factor-8c (FGF-8c), Mouse

Cat. No.
1 mg

Protein Fibroblast Growth Factor-8c (FGF-8c), Mouse
Fibroblast growth factor 8, FGF-8, Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8, Fgf8
FGF-8c, MouseDocument-MSDS: Z03075_MSDS.pdf (pdf)
> 95% by SDS-PAGE and HPLC analyses.
Endotoxin Level
< 0.2 EU/μg, determined by LAL method.
Biological Activity
ED50 < 150 ng/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 6.7× 103 units/mg.
E. coli
Amino Acid Sequence
Gln23-Arg268 (Accession number: P37237, isoform c), expressed with an N-terminal Met.
Molecular Weight
28.2 kDa, observed by reducing SDS-PAGE.
Fibroblast Growth Factor 8c (FGF-8c) is a cytokine belonging to the heparin-binding FGF family, which has at least 23 members. In different species, e.g. human and mouse, FGF-8 has 8 different isoforms, from FGF-8a to FGF-8h. Different FGF-8 isoforms have different affinities to the receptors, thus conduct different signaling cascade pathways. FGF-8 has very widespread expression pattern during embryonic development, and is an organizer and inducer for gastrulation, somitogenesis, morphogenesis, and limb induction. However, FGF-8 is also a potential oncogene: in normal adult cells, FGF-8 has very low expression; on the other hand, FGF-8 is highly expressed in cancer cells of breast, prostate, and ovarian tumors. FGF-8 promotes tumor angiogenesis by increasing neovascularization, and induces osteoblastic differentiation.
Recombinant mouse Fibroblast Growth Factor 8c (rmFGF-8c) produced in E. coli is a single non-glycosylated polypeptide chain containing 247 amino acids. A fully biologically active molecule, rmFGF-8c has a molecular mass of 28.2 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Lyophilized after extensive dialysis against PBS.
Reconstituted in ddH2O at 100 μg/mL.
Lyophilized recombinant mouse Fibroblast Growth Factor 8c (rmFGF-8c) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmFGF-8c should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
For research use only
  • P50011306_Z03075_COA.pdf
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