Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor-8c (FGF-8c), Mouse
Email to GenScript

Fibroblast Growth Factor-8c (FGF-8c), Mouse


Select
Cat. No.
Product Name
Size
Price
Quantity
Z03075-50 FGF-8c, Mouse
50 μg
$159.00
Z03075-10 FGF-8c, Mouse
10 μg
$65.00
Z03075-1 FGF-8c, Mouse
1 mg
$1500.00



Synonyms Fibroblast growth factor 8, FGF-8, Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8, Fgf8
Description Fibroblast Growth Factor 8c (FGF-8c) is a cytokine belonging to the heparin-binding FGF family, which has at least 23 members. In different species, e.g. human and mouse, FGF-8 has 8 different isoforms, from FGF-8a to FGF-8h. Different FGF-8 isoforms have different affinities to the receptors, thus conduct different signaling cascade pathways. FGF-8 has very widespread expression pattern during embryonic development, and is an organizer and inducer for gastrulation, somitogenesis, morphogenesis, and limb induction. However, FGF-8 is also a potential oncogene: in normal adult cells, FGF-8 has very low expression; on the other hand, FGF-8 is highly expressed in cancer cells of breast, prostate, and ovarian tumors. FGF-8 promotes tumor angiogenesis by increasing neovascularization, and induces osteoblastic differentiation.
Recombinant mouse Fibroblast Growth Factor 8c (rmFGF-8c) produced in E. coli is a single non-glycosylated polypeptide chain containing 247 amino acids. A fully biologically active molecule, rmFGF-8c has a molecular mass of 28.2 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Amino Acid Sequence
MQVRSAAQKR GPGAGNPADT LGQGHEDRPF GQRSRAGKNF
TNPAPNYPEE GSKEQRDSVL PKVTQRHVRE QSLVTDQLSR
RLIRTYQLYS RTSGKHVQVL ANKRINAMAE DGDPFAKLIV
ETDTFGSRVR VRGAETGLYI CMNKKGKLIA KSNGKGKDCV
FTEIVLENNY TALQNAKYEG WYMAFTRKGR PRKGSKTRQH
QREVHFMKRL PRGHHTTEQS LRFEFLNYPP FTRSLRGSQR
TWAPEPR
Source E. coli
Species Mouse
Biological Activity ED50 < 150 ng/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 6.7× 103 units/mg.

Molecular Weight 28.2 kDa, observed by reducing SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Purity > 95% by SDS-PAGE and HPLC analyses.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse Fibroblast Growth Factor 8c (rmFGF-8c) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmFGF-8c should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

FGF-8c, Mouse

FGF-8c, Mouse




Notice there is no results found, you can visit "Citations Database" for other results.

FAQs

COAs

MSDS

SDS

Protocols

For more documents, please visit "Technical Support".