Chemical Protein Synthesis Service

The expression of proteins in engineered cells has become a mature technology. However, the limitations of this technology, such as toxicity, uncontrolled processing and modifications, and the constraints of amino acid availability, still interrupt what ought to be a smooth process. Chemical protein synthesis as a complement to protein expression can overcome those problems. The technology produces functional proteins directly from genome sequence data, allowing researchers to dissect the molecular basis of protein function and examine protein-inspired nanofabrication.

GenScript is the first and only company in the industry to provide a chemical protein synthesis service. Our service is based on our proprietary segment condensation and advanced peptide synthesis technologies.

GenScript can synthesize proteins of up to 300 residues.

Key Features:

• High Purity: We can deliver proteins of over 95% purity.
• High Activity: All delivered proteins are refolded to their natural state if required.
• Higher Stability: Unstable proteins, such as proteases, can be stabilized by targeted modifications.
• Engineered Proteins: Engineered proteins can be tailored to have any unnatural amino acid at any position.

Applications:

The applications of chemical protein synthesis cover a wide range of laboratory and clinical tools and processes:

• Non-coded amino acids: Incorporation of non-coded amino acids into proteins
• Protein structure-function relationships: Elucidation of the structural origins of protein function
• Protein backbone engineering: Systematic modification of polypeptide backbone structure for protein function studies
• Intermolecular hydrogen bonding: Interaction analysis of the protein complex containing backbone-to-backbone amide hydrogen bonds
• Mirror image D-proteins: Synthesis of an entire protein with D-amino acids
• Protein signature analysis: Signature analysis of self-encoded libraries of protein analogs
• Precision labeling: Precise labeling at predetermined sites with complete versatility

Services:

GenScript's chemical protein synthesis provides clients with a comprehensive package of active engineered protein synthesis services, including functional characterization. Every step of our chemical protein synthesis process is subjected to stringent quality control. The activity and purity levels of GenScript's engineered proteins are guaranteed.

Delivery Specifications:

The typical delivery consists of engineered proteins in lyophilized powder form, all possessing the specified sequences, modifications, purities, and quantities. The associated QC reports and functional characterization data, where applicable, are included.

Quotations and Ordering:

Please send quotation requests via our secure and easy online messaging system or by email at peptide@genscript.com. In the body of the message, please include the following:

1. The sequence of the protein.
2. Any modifications, specifying the position and residue desired.
3. Quantity and purity requirements.
4. Indicate whether the protein should be refolded.
5. Specify any functional characterization requirements.

Orders can be placed by email, phone, or fax with a formal PO (Purchase Order) or credit card. We recommend that you submit your protein sequence via our Secure Web Sever.

	Order by email: peptide@genscript.com
	Order by phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
	Order by fax: 1-732-210-0262 1-732-885-5878