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Random Library

Random library is an indispensable tool for sequence optimization. It has the ability to generate alternative peptides that could have the potential for enhanced activity. We substitute selected residues randomly and simultaneously with all other 20 natural amino acids via a shotgun approach. Our random library fabricates as many variations as possible within the selected amino acid residues.

Overlapping Peptide
  
Alanine Scanning
     
Truncation Library
  
Positional Scanning
     
Random Library
  
Scrambled Library

References

  • Lam KS. Application of combinatorial library methods in cancer research and drug discovery. Anticancer Drug Des. Apr 1997: 12(3): 145-67
  • Marasco D, Perretta G, Sabatella M, and Ruvo M. Past and future perspectives of synthetic peptide libraries. Curr. Protein Pept. Sci. Oct 2008; 9(5): 447-67.
  • Menendez A, and Scott JK. The nature of target-unrelated peptides recovered in the screening of phage-displayed random peptide libraries with antibodies. Anal. Biochem. Jan 2005 15; 336(2): 145-57
  • Irving MB, Pan O, and Scott JK. Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics. Curr. Opin. Chem. Biol. Jun 2001; 5(3): 314-24.
  • Yang M, Wu Z, and Fields S. Protein-peptide interactions analyzed with the yeast two-hybrid system. Nucleic Acids Res. Apr 1995; 11; 23(7): 1152-6.