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Synthetic Biology

Synthetic Biology applies engineering principles to biological systems, by designing and building new DNA parts to turn cells into useful machines to produce biofuels, medicines, and other economically important organic materials. Gene Synthesis has revolutionized synthetic biology through the de novo chemical synthesis of new DNA molecules encoding novel or optimized proteins, metabolic circuits, or even whole genomes. Gene synthesis expands the possibilities for custom-designing DNA sequences for specific applications in a more powerful and efficient manner than older recombinant DNA technology that required naturally-occurring template DNA as a starting material. As a pioneer in gene synthesis technology and a leader among synthetic biology companies worldwide, GenScript is proud to enable a new era of synthetic biology that will yield new insights into the fundamental principles of life as well as new advances in energy, medicine, and other economically important endeavors.

Synthetic Biology Research Areas

International Genetically Engineered Machine competition (iGEM)International Genetically Engineered Machine competition (iGEM)

Synthetic Yeast Genome Project, Sc2.0
Synthetic Yeast Genome Project, Sc2.0

Protein Engineering
Protein Engineering

Metabolic Engineering
Metabolic Engineering

CRISPR genome editing 
CRISPR genome editing

Therapeutic Antibodies
Therapeutic Antibodies

GenScript Services for Synthetic Biology Research

Synthetic Biology Webinars

Featured Publications in Synthetic Biology

gene news

Synthetic HCV genome engineered with mutations enabling in vitro infectivity:
an important new tool to support HCV research and vaccine development

Synthetic HCV genome engineered with mutations enabling As HCV-related liver disease claims hundreds of thousands of lives each year, Hepatitis C Virus research has thus far been hampered by a lack of infectious cell-culture systems to support basic and translational research including vaccine development. A new paper in J.Virology reports a breakthrough in developing in vitro infectious clones for the most common HCV strains. These researchers synthesized HCV-1 and H77 prototype genomes containing specific mutations that enable infectious particle production in cell culture.


Synthetic Biology Book Li et al. Efficient infectious cell culture systems of the hepatitis C virus prototype strains HCV-1 and H77. J Virol. 2014 Oct 29. pii: JVI.02877-14. Read Free Full Text

gene news

Paper-based gene circuits allow an Ebola sensor to be developed in a single day

Paper-based gene circuits allow an Ebola sensor to be developed in a single day A new paper in Cell reports a breakthrough technique to bring synthetic biology out of the lab. By freeze-drying biological components and embedding them in paper, researchers can rapidly create new cell-free transcription-based detectors that can be used anywhere, without relying on laboratories with sterile cell culture facilities. As a proof-of-principle, they developed a paper-based Ebola virus detector in a single day.

Synthetic Biology Book Pardee et al. Paper-Based Synthetic Gene Networks Cell. 2014 Nov 6. 159(4):940–954. Read Free Full Text

gene news

Building bigger DNA: 3D DNA structures on nanometer scale

Building bigger DNA: 3D DNA structures on nanometer scale In addition to its familiar function of encoding genetic information, DNA is a valuable biomaterial for fabricating customized nanostructures. DNA's ability to self-assemble into precise 3-D structures used in applications from drug delivery to electronic components. A new study reports the creation of scaffolded DNA origami structures far larger than previously described, thanks to two major technological improvements: the use of longer DNA scaffolds and the use of a new chip-based platform for inexpensive synthesis of 1600 DNA sequences serving as staples.

Synthetic Biology Book

Marchi et al. Toward larger DNA origami. Nano Lett. 2014 Oct 8;14(10):5740-7. Read Free Full Text

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The products and services in this section are Research Use Only. Not for use in human clinical diagnostics or therapeutics or in vitro diagnostic procedures.

 
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