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Human Tumor Cell Line Profiling
Cell Line Services

Human Tumor Cell Line Profiling

Oncology drug discovery requires knowing the pharmacological mechanism, and efficacy of small molecules on human tumor cell lines. GenScript offers a comprehensive oncology drug discovery platform which includes antibody drug discovery, in vitro and in vivo pharmacology services. As part of our in vitro oncology services, the cost-efficient human tumor cell line profiling packages, OncoProfiler and XenoProfiler, provide you with a combined panel of over 240 human tumor cell lines as well as a range of high throughput screening (HTS) options. XenoProfiler is a panel of tumor cell lines that have been validated in vivo with xenograft models. Together, OncoProfiler and XenoProfiler not only provides efficacy data in human tumor cell lines, but can ensure translation of efficacy from in vitro to in vivo models

Key Features

  • High quality assay criteria and short turnaround time
  • OncoProfiler includes 200 human tumor cell lines. XenoProfiler includes 40 cell lines, which have been validated in vivo with xenograft models
  • High throughput screening (HTS) options available (see below)

  • Tumor Cell Line Profiling Assays
  • Case Study

Tumor Cell Line Profiling Assays

As a fully custom service, we offer a wide range of assays to use for proliferation and apoptosis profiles. Additionally, we offer biomarker, cytokine induction and combinatorial drug effect screening.

Profile Assay Description Throughput
Proliferation
Luminescent cell viability assay
384-well
MTT/MTS assay
96-well
LDH assay
96-well
SRB assay
96-well
Apoptosis
Caspase assay
384-well
Annexin V/PI assay
96-well
Other FACS analysis
96-well
Biomarker
Genotyping of cell line
48-well
Sequencing
mRNA expression level
96-well
Cytokine induction 
Cell viability assay with optimized incubation time
96-well
Combinatorial drug effect
Using any of the above assays
Custom
Customer defines assay type for any of the profiles

Tumor/cancer cell lines represented in OncoProfiler and XenoProfiler

More details

Bladder
Gastric
Oral
Rabdomyo Sarcoma
Bone
Kidney
Ovarian
Skin
Brain
Leukemia
Pancreatic
Spleen Macrophage
Breast
Liver
Prostate
Synovial
Cervical
Lung
Rectal
Uterine
Colon
Lymphoma

Related services

  • ADCC & CDC assays – Screen antibody candidates for anti-tumor activity in vitro using NK-92 recombinant cells in an endpoint-based assay
  • Cellular Western assay – Get accurate dose response curves from a cell based assay. Available in 96 or 384 well format, with two near-infrared probes
  • Subcutaneous xenograft models – Study compound effects in vivo using validated models
Cell Line Services

Quotations and Ordering

  • Orders can be placed by phone, email, fax, or online with a formal PO (Purchase Order) or credit card. We recommend that you submit your service requests and orders via our Secure Online Ordering System.
  • For questions and quotation requests, please use our Secure Web Server.