cGMP Peptide Applications
Naturally occurring peptides play important and diverse roles in the biochemistry of all living species. Though peptides exhibit highly specific biological activities, many peptides were not traditionally considered suitable for pharmaceutical applications due to the high cost of peptide manufacturing, and difficulty in targeted cellular delivery. However, with the recent development of new technologies, more stable peptides can be synthesized in a more affordable way, with enhanced peptide bioavailability and delivery methods; therefore, peptides are increasingly recognized as lead molecules in pharmaceutical research.
More than 40 peptide drugs are already on the market for treatment of hypertension, osteoporosis, growth deficiency, severe chronic pain, prostate cancer, asthma, diabetes, blood clotting, bacterial infections, infertility, and HIV. Sales of Zestril for hypertension and Salcatonin for osteoporosis reached over $1 billion in 2006.
The success of a peptide drug often depends on modifying the naturally occurring peptide sequence chemically to improve its stability and bioavailability. Two modifications that increase peptide stability are PEGylation and unnatural amino acid incorporation. Bioavailability is enhanced by conjugation of peptides to surface receptor ligands (lectin, sugars, lipoproteins), antibodies, carrier peptides (TAT), or synthetic receptor ligands. In addition, incorporation of nuclear localization signals can improve subcellular targeting of peptide drugs.
GenScript’s scientists are ready to provide the most adequate and cost-effective synthetic or recombinant solution for your peptide pharmaceutical project.
Quotations and Ordering:
- To request a quotation, please send us a message through our Secure Web Server or call, email, or fax us with a brief description of your project. Our representative will contact you with a quote.
- To order, please download and complete the Order Form and send it to us by email or fax. You can also submit PO/credit card information by phone or via our Secure Web Server.
- For questions, or to inquire about the status of your order contact us by email, phone, fax or via our Secure Web Server.
Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.