Overview

Vaccines have played a major role in protecting human health as one of the main means of controlling infectious diseases. More than 20 high-risk diseases can be currently prevented through vaccination. Additionally, since the cost of vaccination is far lower than the high medical expenses incurred after the disease occurs, vaccines are a health investment with one of the highest rates of return. The importance of vaccines was highlighted during the outbreak of COVID-19, when developing a vaccine was considered one of the most important ways to end the pandemic.

With world-renowned advanced technology platforms and rich production experience, GenScript provides synthesis services for gene, plasmid, peptide, protein, etc., available in several vaccine production grades, including GMP.

Vaccine Development Workflow

Antigen
Discovery
1
Vaccine
Development
2
Pre-clinical
Study
3
Clinical
Development
4

Antigen Discovery

Pathogen Study

vaccine development solutions

In the discovery stage, quickly obtaining the pathogen gene sequence is usually the first critical step for developing vaccines and therapeutic drugs. The next step is to study the mechanism of the pathogen's entry into cells and its structure, function, and immunogenicity. The epitope (also known as antigenic determinant) is the part of the antigen recognized by the immune system that stimulates the immunogenic response. Therefore a deep understanding of the epitope distribution and types provides an essential foundation for vaccine development.

Tumor Study

With the development of immunology research, scientists and physicians have discovered new uses for vaccines, such as to treat some intractable diseases. Therefore, vaccines can have both preventive and therapeutic functions. Therapeutic vaccines belong to specific active immunotherapy, especially tumor therapeutic vaccines are at an important stage of development.

Tumor Specific Antigen Screening

Tumor Specific Antigen Screening

Vaccine Development

Through the years, vaccine technologies have undergone many evolutions, and new vaccine types have been developed. GenScript provides comprehensive solutions for the development of new generations of vaccines, such as recombinant protein vaccines, peptide vaccines, mRNA vaccines, DNA vaccines, and viral vector vaccines.

Pre-clinical Study

In response to vaccination, the immune system develops innate and adaptive immune responses. The innate immune response is triggered immediately to new pathogens not present in the host. The more specific adaptive immune response is developed later and consists of antibody and cellular response. Therefore the level of the vaccine antigen is important in order to generate sufficient adaptive immune response. GenScript can support vaccine development as well as the development of vaccine-specific measuring assays such as neutralizing ELISAs and pseudovirus neutralization tests.

mRNA Vaccine

mRNA Vaccine

Plasmid Linearization

IVT mRNA Production

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Recombinant Protein Vaccine

Recombinant Protein Vaccine

Mammalian CHO Expression

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DNA Vaccine

DNA Vaccine

GenCircle dsDNA Vector

Plasmid Preparation

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Viral Vector Vaccine

Viral Vector Vaccine

AAV Vector One-stop Solution

Lentiviral Vector One-stop Solution

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Clinical Development

The focus of clinical trials is to investigate the safety and effectiveness of vaccines, including the evaluation of vaccine protection efficacy and the exploration of the correlation between immunogenicity indicators and protection. Therefore vaccine samples for clinical trials should be produced under GMP conditions. GenScript can provide RUO and GMP grades of key materials used in vaccine development in research and clinical stages to fully support you in successfully launching vaccines.

mRNA Vaccine

mRNA Vaccine

Plasmid Linearization

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Recombinant Protein Vaccine

Recombinant Protein Vaccine

GMP Cell Banking

Mammalian CHO Expression

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DNA Vaccine

DNA Vaccine

Plasmid Preparation

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Viral Vector Vaccine

Viral Vector Vaccine

AAV Vector One-stop Solution

Lentiviral Vector One-stop Solution

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Peptide Vaccine

Peptide Vaccine

Peptide Synthesis

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GenScript supports vaccine development helping you meet different quality requirements in all production stages, from early research to clinical trials.

Vaccine Development Resources

Explore our technologies and learn more about Vaccine Development Solutions. Find the information and resources you need by browsing through our educational material.

  • Antigen Discovery

  • Vaccine Development

  • Pre-clinical Study

  • Clinical Development

Josh Wang, Ph.D.
Unleash the power of NGS target enrichment by semiconductor

Josh Wang, Ph.D.
R&D Sr. Scientist Genscript USA Inc.

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Dr. Howwing Leung
Boosting Your Therapeutic Discoveries with Peptide Libraries

Dr. Howwing Leung
Field Application Scientist, GenScript

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Dr. Gracie Chia
Neoantigen peptide synthesis service for precision therapeutic discovery

Dr. Gracie Chia
Field Application Scientist, GenScript

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