Overview

Spike protein of SARS-CoV-2 (previously named 2019-nCoV) is composed of a S1 domain and S2 domain. The S1 domain contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. Cell entry of coronavirus depends on the spike (S) protein binding to a cellular receptor and priming by a cellular protease. Studies demonstrate that angiotensin-converting enzyme 2 (ACE2) serves as the cell surface receptor to bind S protein in SARS-CoV-2 and facilitates entry of these coronaviruses into the cell. GenScript has developed single clone-derived stable cell lines with high expression of Spike protein of SARS-CoV-2 or human ACE2 (hACE2) to assist and accelerate COVID-19 research.

Highlights

Validated Expression

Validated Expression

Single Clone

Single Clone

Guaranteed Performance

Guaranteed Performance

Stringent QC standards

Stringent QC standards

Applications

Screening neutralizing antibodies that block SARS-CoV-2 pseudovirus transfection.

Screening antibodies against with ACE2 or Spike protein of SARS-CoV-2.

Evaluating binding affinity between antibodies with ACE2 or Spike protein of SARS-CoV-2.

Using as immunogen for antibody development.

Product List

Protein of Expression Cell Line Cat.No.
ACE2 HEK293/ACE2 Stable Cell Line M00770
ACE2 CHO-K1/ACE2 Stable Cell Line M00771
SARS-CoV-2 Spike protein CHO-K1/Spike Stable Cell Line M00803
SARS-CoV-2 Spike protein HEK293T/Spike Stable Cell Line M00804

Case Study

Resource

Stable Cell Lines Brochure
Stable Cell Lines Brochure

Cell line product catalog including brief introductions, product list and validations.

Free Download
Fc Receptor Cell Lines Flyer
Fc Receptor Cell Lines Flyer

Cell line product catalog including brief introductions, product list and validations.

Free Download

Related Products

REQUEST A QUOTE

feedback

Do you like the current new website?

Hate

Dislike

Neutral

Like

Love

*