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AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1) gene, Homo sapiens
About the AKT1 gene
AKT1 gene encodes a serine-threonine protein kinase, which is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Genomic context of AKT1 gene
The human AKT1 gene is shown in the context of the human genome below. To see information about the AKT1 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human AKT1 and mouse AKT1, as well as on-demand AKT1 ORF clones in 183 other species.
Chromosome 14 - NC_000014.9