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Anti-idiotype Antibody Services

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High Specificity and Sensitivity

Downstream Immunoassay Development Service

Upgraded!Anti-idiotype Antibody Services

An anti-idiotype antibody (anti-ID Ab, see the schematic diagram) binds to the idiotype of another antibody, usually an antibody drug. An idiotype can be defined as the specific combination of idiotopes present within an antibodies complement determining regions. Since anti-ID Abs are capable of binding to antibody drugs within biological fluids, they are commonly used in preclinical setting for antibody drug pharmacokinetics (PK) and pharmacodynamics (PD). Due to the similarity between anti-ID Abs and anti-drug antibodies, anti-ID Abs are also commonly used as a reference standard for antibody drug immunogenicity(immune response, IR) studies.

GenScript has 14 years experience in developing of highly sensitive and specific polyclonal and monoclonal anti-ID Abs to support your antibody drug development. We try to work as closely as possible with our customers to understand their specific downstream application in order to generate their perfect anti-ID. See our case studies.

Anti-Idiotype Antibodies

Type 1. Antigen-blocking 2. Non-blocking 3. Complex-specific
Schematic diagram
Feature Paratope-specific Not Paratope-specific Partially paratope-specific
Antigen binding Inhibitory Not inhibitory Not inhibitory
Application Detect free drug only Detect total drug (free and bound) Detect bound drug typically
Selection Guideline
  • Type 1 or type 2 could be applied to detect antibody drug when having a cell-bound drug target e.g. PD1/PDL1
  • Type 1 & type 2 may both be needed when having a secret drug target e.g. TNF

Features of GenScript Anti-ID Antibodies Service

Anti-ID Package Details

Package Starting Material Type Anti-ID Pair Time
Rodent anti-ID mAb development
  • ≥ 2 mg target antibody drug (customer submit, purity > 85%)
  • 0.5 mg Isotype control or human IgG (GenScript provide, purity > 85%)
1/2 N 3-4
  • 1-2 mL supernatant/parental clone
  • 5 mL final supernatant/subclone
  • Hybridoma cell lines
  • 2-5 mg purified Ab/clone(optional)
  • Anti-ID pair and preliminary sandwich ELISA sensitivity report (optional)
  • COA report
Y 4-5
1&2 Y* 4-5
QC standard: ELISA titer ≥ 1: 64,000; Cross rate with negative control ≤ 5%

* : At least one pairing anti-ID Ab (any kind) is guaranteed to delivery
Note: Complex-specific anti-ID Ab need to be further inquired


Quotation and Ordering

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