Upgraded! Anti-idiotype Antibody Services
An anti-idiotype antibody (anti-ID Ab, see the schematic diagram) binds to the idiotype of another antibody, usually an antibody drug. An idiotype can be defined as the specific combination of idiotopes present within an antibodies complement determining regions. Since anti-ID Abs are capable of binding to antibody drugs within biological fluids, they are commonly used in preclinical setting for antibody drug pharmacokinetics (PK) and pharmacodynamics (PD). Due to the similarity between anti-ID Abs and anti-drug antibodies, anti-ID Abs are also commonly used as a reference standard for antibody drug immunogenicity, anti-drug antibody (ADA) studies.
GenScript has 14 years experience in developing of highly sensitive and specific polyclonal and monoclonal anti-ID Abs to support your antibody drug development. We try to work as closely as possible with our customers to understand their specific downstream application in order to generate their perfect anti-ID. See our case studies »
We also offer ready-made anti-idiotype antibody products. Learn More »
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Anti-Idiotype Antibodies
| Type | 1. Antigen-blocking | 2. Non-blocking | 3. Complex-specific |
|---|---|---|---|
| Schematic diagram |  |
 |
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| Feature | Paratope-specific | Not Paratope-specific | Partially paratope-specific |
| Antigen binding | Inhibitory | Not inhibitory | Not inhibitory |
| Application | Detect free drug only | Detect total drug (free and bound) | Detect bound drug typically |
| Selection Guideline |
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Features of GenScript Anti-ID Antibodies Service
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Highest Possible Affinity
Perfect for picomolar-level immunoassay sensitivity
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Guaranteed Anti-ID Pair
Perfect for ELISA kit development
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Stable & Easy Scale Up
Sequence delivery & gram level recombinant Ab supply
Anti-ID Package Details
| Package | Starting Material | Type | Anti-ID Pair | Time (months) |
Deliverable |
|---|---|---|---|---|---|
| Rodent anti-ID mAb development |
|
1/2 | N | 3-4 |
|
| Y | 4-5 | ||||
| 1&2 | Y* | 4-5 | |||
| QC standard: ELISA titer ≥ 1: 64,000; Cross rate with negative control ≤ 5% | |||||
* : At least one pairing anti-ID Ab (any kind) is guaranteed to delivery
Note: Complex-specific anti-ID Ab need to be further inquired
| Package | Starting Material | Type | Anti-ID Pair | Time (months) |
Deliverable |
|---|---|---|---|---|---|
| Rabbit anti-ID mAb development |
|
1/2 | N | 5-6 |
|
| Y | 6-7 | ||||
| 1&2 | Y* | 6-7 | |||
| QC standard: ELISA titer ≥ 1: 64,000; Cross rate with negative control ≤ 5% | |||||
* : At least one pairing anti-ID Ab (any kind) is guaranteed to delivery
Note: Complex-specific anti-ID Ab need to be further inquired
| Package | Starting Material | Time (months) |
Deliverable |
|---|---|---|---|
| Rabbit anti-ID pAb development |
|
2 |
|
| QC standard: ELISA titer ≥1: 64,000; Cross rate with negative control ≤10% | |||
| Package | Starting Material | Time (months) |
Deliverable |
|---|---|---|---|
| PK/ADA analysis ELISA Kit Development |
|
2 |
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| QC standards: Intra-assay precision ≤ 5%, Inter-assay precision≤ 10%, Recovery range between 100 ± 15% | |||
Case study: PK sandwich ELISA kit parameters
| Features | Specification |
|---|---|
| Sensitivity | 0.295 ng/ml |
| Detection Range | 1.5625-100 ng/ml |
| Precision | Inter-assay： 6.51%; Intra-assay： 3.50%. |
| Recovery | Recovery range of this kit was between 85%-115%. |
| Test Samples | Human serum/plasma, mouse serum/plasma |
| Expiration date | Six months |
| Convenience | All reagents and buffers for the test are include in the kit The test could be completed within 2 hours |
Case study: Immunogenicity bridging ELISA kit parameters
| Features | Specification |
|---|---|
| Sensitivity | 0.2056 ng/ml |
| Detection Range | 1.5625-100 ng/ml |
| Precision | Inter-assay：3.74%; Intra-assay： 2.43%. |
| Recovery | Recovery range of this kit was between 85%-115%. |
| Test Samples | Human serum/plasma (EDTA), mouse serum, Rat serum/plasma (heparin), Rabbit serum/plasma (heparin) |
| Expiration date | Six months |
| Convenience | All reagents and buffers for the test are include in the kit The test could be completed within 2 hours |
Quotation and Ordering
Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.
