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GnRHR Antibody, mAb, Mouse

*This product has been discontinued! *
Synonyms Mouse Anti-GnRHR mAb; Anti GnRHR (monoclonal)
Description Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. Activin A has been shown to stimulate the synthesis of GnRHR, illustrating a possible mechanism for the modulation of gonadotropin responsiveness to GnRH.
Host Species Mouse
Antigen Species Human
Conjugation Unconjugated
Immunogen A mixture of peptides from different regions of GnRH receptor protein
Purification Immunoaffinity purification

Subclass Mouse Monoclonal (IgG)
Clone ID A00086.01
Concentration 1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
Specificity Recognize specifically GnRH receptor from human and other species not tested
Species Reactivity Human
Storage The antibody will remain stable for one year from the date of shipment if stored at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap and avoid repeated freezing and thawing. Aliquots will remain stable for three months if stored at 4°C.

Western blot: 1:1,000
Immunohistochemistry: 1:200
This antibody reacts with GnRH receptors in the anterior pituitary. GnRH functions as a stimulator of gonadotrophs to release luteinizing hormone (LH) and follicle stimulating hormone (FSH).

Pask AJ, et al. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol. Endocrinol. Apr 2005; 19 (4): 972-981.

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