Catalog Products » Other Products » LPL Antibody, mAb, Mouse

LPL Antibody, mAb, Mouse

*This product has been discontinued! *
Synonyms Mouse Anti LPL (monoclonal); Mouse Anti LPL
Description Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF) secretion and induction of vascular smooth muscle cell proliferation.
Host Species Mouse
Antigen Species Human
Conjugation Unconjugated
Immunogen Human LPL whole protein
Purification Immunoaffinity purification

Subclass Mouse IgG1
Clone ID A00090.01
Concentration 1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
Specificity Recognize specifically LPL from human and bovine
Species Reactivity Human and bovine
Storage The antibody remains stable for one year from date of shipment if stored at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will remain stable at 4°C for three months.

Western blot: 1:100
ELISA: 1:200-500 in lipid metabolic research

Yin B, et al. Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium. J. Clin. Invest. Aug 1997; 100(3): 649-657.

Ikeda Y, et al. A sandwich-enzyme immunoassay for the quantification of lipoprotein lipase and hepatic triglyceride lipase in human postheparin plasma using monoclonal antibodies to the corresponding enzymes. J. Lipid Res. Oct 1990; 31 (10): 1911-1924.

Pyle DM.,et al. IgE cross-linking critically impairs human monocyte function by blocking phagocytosis.J Allergy Clin Immunol.2013Feb;131(2):491-500

Sun L.,et al. Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.PLoS One.2012Feb;7(2):e30802

You can visit "Citations Database" for more citations.

For more documents, please visit "Technical Support".

24 hour