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SRY Antibody, mAb, Mouse

*This product has been discontinued! *
Synonyms Mouse Anti-SRY mAb; Anti SRY (monoclonal)
Description The Sex-Determining Region (SRY) is a gene that encodes a transcription factor that is a member of the high mobility group HMG-box family of DNA binding proteins. The gene is located on the short arm of the Y chromosome and has a gene map locus - Yp11.3. Common synonyms of the gene name are Testis Determining Factor (TDF) and Testis Determining Factor on Y (TDY). The main function of the SRY protein is to initiate male sex determination as a transcriptional activator, which regulates a genetic switch in male development. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. The SRY protein then binds to the DNA and distorts its shape (SRY protein in action). In doing so, it regulates genes that control the development of the testes.
Transcriptional activator which regulates a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove.
Host Species Mouse
Antigen Species Mouse
Conjugation Unconjugated
Immunogen SRY-GST fusion protein
Purification Immunoaffinity purification

Subclass Mouse monoclonal IgG
Clone ID A00094.01
Concentration 1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
Specificity Recognize mouse SRY protein, others not tested
Species Reactivity Mouse
Storage Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stale at 4°C for 3 months.

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Hossain A, Saunders GF. The human sex-determining gene SRY is a direct target of WT1. J. Biol. Chem. May 2001; 276(20): 16817-16823.

Yu X, Weissman SM. Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts. J. Biol. Chem. Nov 2000; 275(44): 34597-34608.

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