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Apo CI Antibody, pAb, Rabbit

*This product has been discontinued! *
Synonyms Rabbit Anti-Human Apo CI pAb; Anti Human Apo CI
Description The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein.
At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
Host Species Rabbit
Antigen Species Human
Conjugation Unconjugated
Immunogen Apo CI recombinant protein
Purification Immunoaffinity purification

Subclass Rabbit IgG
Concentration 1 mg/ml, PBS, pH 7.4 with 0.05% sodium azide.
Specificity Specially binds to human apo CI
Species Reactivity Human
Storage Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stale at 4°C for 3 months.

Western blot: 1:2,500-1:10,000
ELISA: 1:2,500-1:10,000
Technical Manual ELISA Protocol(pdf)
Western Blot Protocol(pdf)
FACS Protocol(pdf)
IHC Protocol(pdf)
IP Protocol(pdf)

Cat. No.
Product Name
A00122 Apo CII Antibody, pAb, Goat
100 ug
A00124 Apo CIII Antibody, pAb, Goat
100 ug
Taddei-Peters WC, et al. Quantification of lipoprotein(a) particles containing various apolipoprotein(a) isoforms by a monoclonal anti-apo(a) capture antibody and a polyclonal anti-apolipoprotein B detection antibody sandwich enzyme immunoassay. Clin. Chem. Jul 1993; 39(7): 1382-1389.

Clavey V, et al. Modulation of lipoprotein B binding to the LDL receptor by exogenous lipids and apolipoproteins CI, CII, CIII, and E. Arterioscler Thromb Vasc. Biol. Jul 1995; 15(7): 963-971.

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