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Catalog Products » Antibodies » Primary Antibodies » Alzheimer's Disease Antibody list » β-Amyloid Antibody (1-17), pAb, Rabbit

β-Amyloid Antibody (1-17), pAb, Rabbit

β-Amyloid Antibody (1-17), PAb, Rabbit

Immunofluorescent analysis of human Alzheimer Disease’s brain hippocampus tissue slide (Biochain, T2236052Alz) using
Rabbit Anti-β-Amyloid (1-17) Polyclonal Antibody (GenScript, A00685)

β-Amyloid Antibody (1-17), PAb, Rabbit

Western blot analysis of human β-Amyloid 1-40 and β-Amyloid 1-42 peptides using
Rabbit Anti-β-Amyloid (1-17) Polyclonal Antibody (GenScript, A00685)

Synonyms Rabbit Anti beta-Amyloid (1-17) pAb;
Description A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease. βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation endproducts. Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease. β-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.
Host Species Rabbit
Antigen Species Human
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to amino acids 1-17 of β-amyloid conjugated to KLH
Purification Immunoaffinity chromatography

Subclass Rabbit IgG
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.
Specificity This antibody is specific to human β-amyloid 1-40 and β-amyloid 1-42 peptides.
Species Reactivity Human
Storage The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

  • β-Amyloid Antibody (1-17), PAb, Rabbit
  • β-Amyloid Antibody (1-17), PAb, Rabbit

    Immunofluorescent analysis of human Alzheimer Disease’s brain hippocampus tissue slide (Biochain, T2236052Alz) using
    Rabbit Anti-β-Amyloid (1-17) Polyclonal Antibody (GenScript, A00685)

  • β-Amyloid Antibody (1-17), PAb, Rabbit
  • β-Amyloid Antibody (1-17), PAb, Rabbit

    Western blot analysis of human β-Amyloid 1-40 and β-Amyloid 1-42 peptides using
    Rabbit Anti-β-Amyloid (1-17) Polyclonal Antibody (GenScript, A00685)




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Cat. No. A00685
Size
Price
40 ug $99.00
100 ug $199.00