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Catalog Products » Antibodies » Primary Antibodies » Alzheimer's Disease Antibody list » β-Amyloid Antibody (1-17), pAb, Rabbit

β-Amyloid Antibody (1-17), pAb, Rabbit

*This product has been discontinued!*
Specificity This antibody is specific to human β-amyloid 1-40 and β-amyloid 1-42 peptides.
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids 1-17 of β-amyloid conjugated to KLH
Species Reactivity Human
Conjugate Unconjugated

Working concentrations for specific applications should be determined by the investigator.Appropriate concentrations will be affected by several factors, including secondary antibody affinity, antigen concentration, sensitivity of detection method, temperature, and length of incubations, etc.The suitability of this antibody for applications other than those listed below has not been determined.The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
ELISA 0.1-1.0 µg/ml
Western Blot 0.1-1.0 µg/ml
Immunofluorescence 5-20 µg/ml
Other applications User-optimized

Form Lyophilized
Storage Buffer Lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Storage Instructions The antibody is stable in lyophilized form if stored at -20°C or below.The reconstituted antibody can be stored for 2-3 weeks at 2-8°C.For long term storage, aliquot and store at -20°C or below.Avoid repeated freezing and thawing cycles.
Purification Affinity chromatography
Isotype Rabbit IgG
Clonality Polyclonal
Clone ID Not applicable

Target Background A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease.βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent.Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation endproducts.Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme.Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease.β-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.
Synonyms Rabbit Anti beta-Amyloid (1-17) pAb;

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

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Cat. No. A00685