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Catalog Products » Antibodies » Primary Antibodies » Phospho-Specific Antibodies » SNCA Antibody, mAb, Mouse

SNCA Antibody, mAb, Mouse

*This product has been discontinued! *
Synonyms Mouse Anti-SNCA mAb;
Description Alpha-synuclein (SNCA), with 140-amino acid protein (about 15,000 Da), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
Host Species Mouse
Antigen Species Human
Immunogen Ni-NTA purified truncated recombinant SNCA expressed in E. coli strain BL21 (DE3).

Clone ID A00811.01
Concentration 1 mg/ml in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Specificity Truncated SNCA recombinant protein (WB), human SNCA recombinant protein (ELISA), human glioma tissue (IHC)
Storage This product remains stable for one to two weeks if stored at 2°C to 8°C. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. Use before is one year from the date of receipt.

Western blot: 1:500-1:2,000
IHC(P): 1:500-1:2,000
IHC(F): 1:500-1:2,000
ELISA: Propose dilution 1:10,000
Determine optimal working dilutions by titration test.
Technical Manual ELISA Protocol(pdf)
Western Blot Protocol(pdf)
FACS Protocol(pdf)
IHC Protocol(pdf)
IP Protocol(pdf)


J. Johnson, S. M. Hague, M. Hanson Neurology, Aug 2004; 63: 554 - 556

Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie Protein Pept Lett. 2006;13(4):385-90.

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