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Catalog Products » Other Products » PIN1 Antibody, pAb, Rabbit

PIN1 Antibody, pAb, Rabbit

Synonyms Rabbit Anti-PIN1 pAb;
Description PIN1 is an essential peptidyl-prolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity. It displays a preference for an acidic residue N-terminal to the isomerized proline bond. It catalyzes pSer/Thr-Pro cis/trans isomerizations. PIN1 has been implicated in tau pathologies that underlie Alzheimer's disease. PIN1 binds to tau-phosphorylated sites, specifically on the Thr231-Pro site, where it induces conformational changes. PIN1 may be pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration.
GenScript Rabbit Anti-PIN1 Polyclonal Antibody is developed in rabbit hosts using a KLH-coupled synthetic peptide within residues 50-100 of human PIN1 protein (Swiss Prot: Q13526).
Host Species Rabbit
Antigen Species Human
Conjugation Unconjugated
Immunogen Synthetic peptide (KLH-coupled) within residues 50-100 of human PIN1 protein (Swiss Prot: Q13526)
Purification Immunoaffinity chromatography

Subclass Rabbit IgG
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Specificity GenScript Rabbit Anti-PIN1 Polyclonal Antibody detects human PIN1 protein. Sequence homology predicts that it will also react with rat and mouse PIN1 proteins.
Species Reactivity Human. This product has not yet been tested with other species.
Predicted Band Size 57 kD
Observed Band Size 57 kD
Storage The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Note Small volumes of antibody will occasionally become trapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.2 µg/ml
Western blot: 0.5-1 µg/ml
Other applications: user-optimized

  • PIN1 Antibody, PAb, Rabbit
  • PIN1 Antibody, PAb, Rabbit

    Western blot analysis of human recombinant PIN1 fusion protein using PIN1 Antibody , pAb, Rabbit (GenScript, A01090, 1 µg/ml)
    The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG.
    Predicted Size: 57 kD
    Observed Size: 57 kD




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Cat. No. A01090
Size
Price
40 ug $99.00