| A01874 | |
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| Specificity | The product is specific for human CD38. This antibody binds with recombinant CD38 protein in ELISA and human CD38 expressing cell line in flow cytometry assay. |
| Host Species | Mouse |
| Immunogen | Recombinant human CD38 |
| Conjugate | Unconjugated |
| Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product. | |||||||
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| Form | Lyophilized |
| Storage Buffer | lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. |
| Reconstitution | Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/mL. |
| Storage Instructions | The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles. |
| Purification | Protein A affinity column |
| Isotype | Mouse IgG1,κ |
| Clonality | Monoclonal |
| Clone ID | 38.F2 |
| Note | GenScript can customize this product per customer's request including product size, buffer components, etc. |
| Target Background | CD38 glycoprotein is a particularly attractive target on malignant plasma cells at all stages of disease and in Chronic lymphocytic leukemia (also called CLL) patients with a poor clinical prognosis. It is highly expressed in lymphoid tumors including multiple myeloma, AIDS-associated lymphomas, and post-transplant lymphoproliferation. In contrast, the molecule is detectable only at very low levels in mature lymphocytes or in nonhematopoietic tissues. Therputic Anti-CD38 antibodies (e.g. Daratumumab) can induce strong antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity to kill tumors.GenScript Anti-Human CD38 Antibody (38.F2), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human CD38. |
| Synonyms | Mouse monoclonal to 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase,cyclic ADP-ribose hydrolase 1, ADPRC 1, cADPr hydrolase 1, CD38, CD38 antigen (p45), CD38 antigen p45, cluster |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
