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BARD1 gene (BRCA1 Associated RING Domain 1) gene, Homo sapiens

Do you need expression-ready BARD1 Gene to study the functions and characteristics? GenScript offers BARD1 gene in any custom vector for your molecular biology studies by ordering an BARD1 ORF Clone.

About the BARD1 gene

BARD1 gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Genomic context of BARD1 gene

The human BARD1 gene is shown in the context of the human genome below. To see information about the BARD1 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human BARD1 and mouse BARD1, as well as on-demand BARD1 ORF clones in 183 other species.

Chromosome 2 - NC_000002.12

Chromosome 2 - NC_000002.12

Genomic sequence of BARD1 gene

Genomic sequence of BARD1 gene


1.BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility. —— Fu W, et al. EBioMedicine, 2017 Feb. PMID 28161399
See all (203) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene

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