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BARD1 gene (BRCA1 Associated RING Domain 1) gene, Homo sapiens
About the BARD1 gene
BARD1 gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Genomic context of BARD1 gene
The human BARD1 gene is shown in the context of the human genome below. To see information about the BARD1 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human BARD1 and mouse BARD1, as well as on-demand BARD1 ORF clones in 183 other species.
Chromosome 2 - NC_000002.12
Genomic sequence of BARD1 gene