List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

anti-inflammatory antibody drugs

Anti-inflammatory antibody drugs, also known as anti-cytokine antibody drugs, are a class of therapeutic agents designed to modulate the immune response by targeting specific proteins involved in the inflammatory process. Inflammation is a natural and protective response of the immune system to injury or infection, but in certain conditions, it can become chronic and contribute to various diseases. Anti-inflammatory antibody drugs aim to mitigate this inflammatory response by blocking specific signaling molecules, particularly cytokines, which play a key role in inflammation.

Here are some key points about anti-inflammatory antibody drugs:

1. Mechanism of Action:

These drugs primarily target cytokines, which are signaling proteins involved in immune responses and inflammation.

By blocking specific cytokines, anti-inflammatory antibodies can interrupt the inflammatory signaling cascade and reduce the overall inflammatory response.

2. Conditions Treated:

Anti-inflammatory antibody drugs are used in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel diseases (like Crohn's disease and ulcerative colitis), psoriasis, and certain types of autoimmune arthritis.

3. Common Targets:

• Tumor Necrosis Factor-alpha (TNF-α): Agents like infliximab and adalimumab target TNF-α, a cytokine involved in inflammation and joint destruction.

• Interleukins: Drugs targeting interleukins, such as IL-6 or IL-17A, are used in conditions like rheumatoid arthritis and psoriasis.

• Other Cytokines: Various antibodies target cytokines like IL-1, IL-12, and IL-23, depending on the specific disease and inflammatory pathway.

4. Types of Anti-inflammatory Antibody Drugs:

• Monoclonal Antibodies: These drugs are designed to mimic the immune system's ability to fight off harmful invaders. Monoclonal antibodies can specifically bind to cytokines or immune cells involved in inflammation.

• Fusion Proteins: These are molecules that combine portions of antibodies with other proteins. For example, etanercept is a fusion protein that binds to TNF-α.

• IL-1 Receptor Antagonists: Drugs like anakinra block the action of interleukin-1 (IL-1) by acting as receptor antagonists.

5. Administration:

Anti-inflammatory antibody drugs are often administered by injection or infusion. The frequency of administration can vary depending on the specific drug and the condition being treated.

6. Benefits and Risks:

These drugs can provide significant relief for individuals with inflammatory and autoimmune diseases, improving symptoms and slowing disease progression.

However, there are potential risks, including an increased susceptibility to infections, infusion reactions, and, in some cases, a risk of reactivating latent infections.

7. Examples of Anti-inflammatory Antibody Drugs:

Infliximab (Remicade), adalimumab (Humira): Target TNF-α.

• Rituximab (Rituxan): Targets B cells.

• Tocilizumab (Actemra): Targets IL-6 receptors.

• Secukinumab (Cosentyx): Targets IL-17A.

Anti-inflammatory antibody drugs have revolutionized the treatment of inflammatory and autoimmune conditions, providing a more targeted and effective approach to manage these disorders. However, their use requires careful consideration of individual patient characteristics and potential side effects.


Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Antibody Production Services

Comprehensive custom antibody production services including monoclonal and polyclonal antibody production services with industry leading turnaround times.

Polyclonal Antibody Services

The fastest custom polyclonal antibody production services in the industry with unmatched guarantees.

Custom Monoclonal Antibody Development Services

Developing custom monoclonal antibodies with standard or fully custom protocols including everything from antigen synthesis to antibody scale-up options.

Phospho-Specific Antibody Services

Guaranteed ELISA titer of ≥ 1:64,000 and < 10% cross reactivity with non-phospho peptide.

Immunoassay Development Services

Our custom immunoassay development service offering comprehensive high-throughput assay development with fast turnaround and high efficiency.

Large-scale Antibody Manufacturing

Our large-scale antibody manufacturing services offer polyclonal and monoclonal antibody production of gram quantities for industrial antibody yields.

COVID-19 Reagent Antibodies

On demand SARS-CoV-2 control mAbs ideal for diagnostics, therapeutic, and vaccine development.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.
feedback

Do you like the current new website?

Hate

Dislike

Neutral

Like

Love

*